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Dr. Giuseppe Melacini

Giuseppe Melacini is a Professor in the Department of Chemistry and Chemical Biology and a joint member of the Department of Biochemistry and Biomedical Sciences. Dr. Giuseppe Melacini received his undergraduate degree in Chemistry (1992) and his Ph.D. in Biophysical Chemistry (1996) from the University of Milan with external research at the University of California, San Diego (UCSD).

During his graduate studies, he worked in the area of peptidomimetics under Dr. Murray Goodman at UCSD. Then he moved to the Netherlands for his post-doctoral studies in the laboratories of Dr. Robert Kaptein and Dr. Rolf Boelens at Utrecht University. There he focused on the study of protein hydration by Nuclear Magnetic Resonance spectroscopy (NMR). After returning to UCSD as Lecturer and Assistant Project Scientist, he joined the Departments of Chemistry and Biochemistry at McMaster in 2003.

In 2018-2019 Giuseppe served as Associate Chair of graduate studies in Chemistry, and since July 2019 as Director of the Chemical Biology graduate program. Giuseppe is the recipient of the Biological and Medicinal Chemistry Lectureship Award by the Canadian Soc. of Chem. (2020), the Excellence in Graduate Student Supervision Award (2019), the Natural Sciences and Engineering Research Council - Discovery Accelerator Supplement Award (2014), the McMaster Student Union - Teaching award (2012), the Canadian Institutes of Health Research - Maud Menten Finalist Prize (2007), the Heart & Stroke Foundation of Canada - New Investigator (2006) and Maureen Andrew Awards (2006), the Alzheimer Society of Canada -  Young Investigator Award (2005) and the Premier’s Research Excellence Award (2005).


Giuseppe has served on multiple grant review panels in Canada and has reviewed US, European and Israeli grant applications. He has been an executive member of the Biophysical Society of Canada for which he chaired the award committee (2014-2019). He has also co-organized and co-chaired several conferences. He has consulted for biopharmaceutical and biotech companies.

He is the author of over 100 manuscripts and is a member of the editorial boards of the Journal of Biological Chemistry and Nature Scientific Reports. He has served as associate editor for the Journal of Alzheimer’s Disease and as invited expert editor for the Proceedings National Academy Science USA (PNAS).
Giuseppe is very proud to have something in common with Jeff Bezos and Bill Gates – he does the dishes every night.

If you are interested in learning more about my research you can watch some of my talks:

CIC Talks: Allosteric Regulation of Protein Kinases

Allosteric Network Detection using CHESCA

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