Our research focuses mainly on signalling, kinases, and intrinsically disordered proteins (IDPs). Kinases and IDPs play a critical role in cancer and neurodegeneration, respectively.
Several cancers are caused by the overactivation of kinases and by the resulting deregulation of cell signaling. We are interested in understanding the molecular basis of selective kinase inhibitors that hold promise in cancer treatment. Read more about our work on kinase inhibitors here or watch this video.
Most neurodegenerative diseases are linked to the self-association of amyloid-forming peptides and proteins. We focus on the mechanism of action of amyloid inhibitors that suppress pathogenic oligomerization pathways. Read more about our work on amyloid inhibitors here.
Our primary tool to investigate the molecular mechanisms of kinase and amyloid inhibitors is Nuclear Magnetic Resonance (NMR) spectroscopy. We complement NMR with several other techniques for protein biochemistry and biophysics (e.g. protein purification, fluorescence, MS, DLS, SPR, ITC etc.).